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Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
必威体育登录手机This application note describes the analysis of tryptic digests of a monoclonal antibody and an antibody-drug conjugate using an Agilent 1290 Infinity II LC with an Agilent AdvanceBio Peptide Map column.
This application note presents different approaches to native mass spectrometry.
A method describing the detection of 12 potentially mutagenic nitrosamine impurities found in sartan drugs using the Ultivo LC/TQ
| Korean (Korea) | Complete (PDF) |
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| Chinese (Simplified) (China) | Complete (PDF) |
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必威体育登录手机Sensitive, high-resolution LC/MS/MS method using the Agilent 6546 LC/Q-TOF for the detection and quantification of the nitrosamine impurities
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| Japanese (Japan) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
Analysis of charge variants of Rituximab (both innovator and biosimilar molecules) using multiple heart-cutting 2D-LC with MS detection
This Application Note describes a routine analysis workflow for pharmaceutical QA/QC labs.
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This work presents a novel tool to study E&L compounds with enhanced flexibility and confidence using a high-resolution accurate mass GC/Q-TOF
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Reliable detection of short chain (C1-C7) fatty acids by GC/MS in feces, without drying the samples
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| Korean (Korea) | Complete (PDF) |
必威体育登录手机Agilent 1260 Infinity II Prime LC with ISET – emulation of the Agilent 1200 Series Quaternary LC for analysis of antihistaminic drugs.
| Chinese (Simplified) (China) | Complete (PDF) |
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The detection of low-level impurities contained in a sample of a structurally related main compound using high‑resolution sampling 2D-LC is shown.
This application note describes a workflow for assessing critical quality attributes (CQAs) of intact adeno-associated viruses (AAVs), together with post-translational modification (PTM) identification of the capsid proteins.
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必威体育登录手机This application note demonstrates the use of an Agilent 1260 Infinity II Bio-Inert LC System coupled to an Agilent InfinityLab LC/MSD iQ with an automated column selection valve for spent media analysis and protein A-based titer determination....
This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
必威体育登录手机This application note describes the fully automated and in-depth characterization of monoclonal antibody (mAb) charge variants by four-dimensional liquid chromatography/mass spectrometry (4D-LC/MS) using the Agilent InfinityLab 2D-LC Solution and...
| Chinese (Simplified) (China) | Complete (PDF) |
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| Japanese (Japan) | Complete (PDF) |
This Application Note presents an integrated workflow for peptide mapping of a mAb with Iterative MS/MS from automated sample preparation to data analysis.
必威体育登录手机In this chapter, the Agilent solution suitable for the measurement of peptide mapping is discussed in the context of characterizing NISTmAb.
必威体育登录手机In this chapter, the Agilent solution suitable for the measurement of variant analysis is discussed in the context of characterizing NISTmAb.
必威体育登录手机In this chapter, the Agilent solution suitable for the measurement of intact analysis by HIC is discussed in the context of characterizing NISTmAb.
必威体育登录手机Agilent-NIST mAb application compendium chapter Intact Analysis.