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必威体育登录手机This application note describes the analysis of tryptic digests of a monoclonal antibody and an antibody-drug conjugate using an Agilent 1290 Infinity II LC with an Agilent AdvanceBio Peptide Map column.
Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
This application note presents different approaches to native mass spectrometry.
必威体育登录手机This application note describes use of the Agilent AdvanceBio sialic acid profiling and quantitation kit (p/n GS24-SAP) to profile sialic acid species present and perform absolute sialic acid quantitation.
Use of 6545XT LC/Q-TOF to analyze poly-A tail sequences formed by E.coli Poly-A Polymerase (PAP), which is a common component of in vitro transcription systems.
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| Chinese (Simplified) (China) | Complete (PDF) |
必威体育登录手机An overview of the separation and characterization of Emicizumab, using a variety of products from the Agilent biocolumns portfolio.
| Japanese (Japan) | Complete (PDF) |
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During the drug discovery process, permeability assays such as Caco-2 (cell line) and PAMPA (parallel artificial membrane permeation assay) are utilized to mimic the absorption of potential drug candidates by the cells of the human intestine.
必威体育登录手机A demonstration of the consistent and reliable performance of the Agilent Bio-Monolith rProtein A column antibody in titer analysis.
| Italian (Italy) | Complete (PDF) |
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| German (Germany) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
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In this application note, we have developed a mass spectrometry-compatible, native-mode size exclusion (SEC/MS) method for characterization of a challenging FDC with very low pI.
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| Korean (Korea) | Complete (PDF) |
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In this application note, we show an alternative analysis of LMW species of mAbs based on the excellent performance of the 1290 Infinity II Bio LC and the PEEK-lined PLRP-S column.
| Chinese (Simplified) (China) | Complete (PDF) |
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| Korean (Korea) | Complete (PDF) |
| Japanese (Japan) | Complete (PDF) |
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This application note shows that there are numerous variables available for optimization of the analytical conditions for oligonucleotides.必威体育登录手机The analyses were carried out on an Agilent 1290 Infinity II LC System with UV detection by DAD and an...
| Chinese (Simplified) (China) | Complete (PDF) |
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| Japanese (Japan) | Complete (PDF) |
Analysis of charge variants of Rituximab (both innovator and biosimilar molecules) using multiple heart-cutting 2D-LC with MS detection
Analysis of radiogenic REE isotopes in bulk REE matrices
必威体育登录手机This application note demonstrates the superior resolution in size exclusion chromatography (SEC) protein separation made possible by the Agilent 1290 Infinity II Bio LC System equipped with the Agilent AdvanceBio SEC column and ultralow dispersion...
| Chinese (Simplified) (China) | Complete (PDF) |
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This application note demonstrates the DAR determination of brentuximab vedotin using HIC.
| Chinese (Simplified) (China) | Complete (PDF) |
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必威体育登录手机In this application note, we present the new Agilent 1290 Infinity II Bio LC as the system of choice for peptide mapping.
| Chinese (Simplified) (China) | Complete (PDF) |
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必威体育登录手机This application note describes a method for automated MHC-I associated peptide enrichment using the Agilent AssayMAP Bravo platform with large-capacity (25 µL) cartridges for immunopeptidomics analysis.
| Chinese (Simplified) (China) | Complete (PDF) |
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必威体育登录手机This application note showcases the quantitative performance of multiple reaction monitoring (MRM)-based LC/MS analysis of peptides derived from protein biomarkers in human plasma using the Agilent 1290 Infinity II LC system coupled to the Agilent...
LC/MS peptide mapping approach to characterize and quantify different monoclonal antibody critical quality attributes.
| Korean (Korea) | Complete (PDF) |
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| Japanese (Japan) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
Compendium of 5 app notes describing multiple attribute methodology for critical quality attribute characterization.