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Aggregate and Fragment Analysis of Adeno-Associated Viral Vectors using Size Exlusion is a critical analysis.Bio SEC-5 demonstrates reproducible separation and resolution of these AAV particles and aggregates.
Virus-like particles (VLPs) are highly structured protein particles that are self-assembled from one or more structural proteins, typically 20 to 150 nm in diameter.
必威体育登录手机An SEC method identifying innovator and biosimilar insulin analog was developed using an Agilent AdvanceBio SEC 130Å, 7.8 × 300 mm, 2.7 μm column.
Evaluation of SEC Columns for Analysis of ADC Aggregates and Fragments - Choosing the best stationary phase to overcome nonspecific interactions.
必威体育登录手机This collection of 10 Agilent ‘aggregate and fragment analysis' app notes also includes our guide on how to perform SEC for biomolecule analysis.
必威体育登录手机An overview of the separation and characterization of Emicizumab, using a variety of products from the Agilent biocolumns portfolio.
In this application note, we have developed a mass spectrometry-compatible, native-mode size exclusion (SEC/MS) method for characterization of a challenging FDC with very low pI.
Nanobody analysis with AdvanceBio SEC 120 Å 1.9 μm column for size exclusion chromatography and AdvanceBio HIC column hydrophobic interaction chromatography (HIC)
Comparison of AdvanceBio SEC 200 Å 1.9 µm column for SEC analysis of hGH, hG-CSF and IFN alpha-2b therapeutic proteins with sub-2 µm particle columns from other vendors.
必威体育登录手机Presents a method for the rapid analysis of a monoclonal antibody using the Agilent AdvanceBio SEC 200 Å 19 µm column.
Comparison of HPLC method and a quick method developed using the Cary 60 UV-Vis
This application note describes a robust LC/MS method for the analysis of native protein analysis.
Improvements in resolution and shorter run times using AdvanceBio SEC 120 Å 1.9 μm, 4.6 x 300 mm column for insulin analysis.
必威体育登录手机Agilent-NIST mAb application compendium
必威体育登录手机Size Exclusion Chromatography Method Development of NIST mAb Using an Agilent AdvanceBio SEC 200 Å, 1.9 µm Column
必威体育登录手机Describes a comparison between the Agilent AdvanceBio SEC 200 Å 1.9 µm column and other vendors' SEC columns in terms of mAb and ADC analysis.
Size exclusion chromatography with light scattering detection was used to investigate the impact of varying SDS concentration on protein molecules.
必威体育登录手机The Agilent AdvanceBio SEC column together with the Agilent 1260 Infinity II Bio-inert System is an ideal combination for the aggregate analysis of ADCs
An aggregate analysis workflow for SEC mobile phase optimization and characterization of mAb aggregation profiles
"This Application Note describes the quantification of aggregates in biotherapeutic