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This application note describes a workflow for assessing critical quality attributes (CQAs) of intact adeno-associated viruses (AAVs), together with post-translational modification (PTM) identification of the capsid proteins.
必威体育登录手机Agilent-NIST mAb application compendium
Presents the use of the AdvanceBio HIC column to resolve monoclonal antibody variants from their native form without mAb digestion into subunits.
必威体育赛事投注This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Describes the use of the new AdvanceBio HIC column, with method optimization, to assess DAR values of ADCs.
An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements
Demonstion of the use of multiple heart-cutting two-dimensional liquid chromatography for automated desalting of glucagon from an MS incompatible USP method.
Identification of monoclonal antibody mutation sites using the 1290 Infinity II 2D-LC solution with 6530 Q-TOF LC/MS.
必威体育登录手机Agilent PLRP-S column demonstrates superior separation performance for the analysis of mAbs and ADC at both intact and fragment levels
AdvanceBio Desalting - RP cartridges used for effective desalting of LC-separated monoclonal antibodies (mAbs) before characterization by mass spectrometry
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
In this paper, we are investigating an antibody drug conjugate (ADC) with a cysteine linker.
Analyzing therapeutic mAbs with AdvancedBio RP-mAb and a 6530 Accurate-Mass Q-TOF LC/MS delivers fast and high-resolution separation of intact and ADC mAbs.
必威体育登录手机"Fast and High Resolution Analysis of Intact and Reduced Therapeutic Monoclonal Antibodies (mAbs) using the Agilent Bio-inert LC and AdvanceBio RP-mAb Columns
必威体育登录手机Reversed-phase LC primary structure characterization workflow using Agilent AdvanceBio RP-mAb columns and Agilent 1260 Infinity Bio-Inert LC system
必威体育登录手机Agilent Bio Mab WCX separates charged variants of papain-digest monoclonal antibody, following by MS characterization of the charged variants with online desalting.
必威体育登录手机An Agilent Bio-Monolith Protein A column determined recombinant mAb titer and was used to enrich µg amounts of antibody for further structural characterization by MS.
The charge heterogeneity provides a great challenge for the complete characterization of the monoclonal antibody (mAb).
This work describes a high flow LCMS method to demonstrate the high resolution mass analysis of mAbs with good chromatography and its utility in analysis of Biosimilar mAbs.
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