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In this application note, we explore some of the key parameters when comparing different column chemistries using ion-pair reversed-phase (IP-RP) separation of Semaglutide.
This application note presents an HPLC method development for the purity testing of semaglutide.
必威体育登录手机The use of an Agilent AdvanceBio Peptide Plus column coupled to the Agilent 6545XT AdvanceBio LC/Q-TOF to optimize large mass loads and sharp peak shapes for host cell protein analysis of AAVs.
必威体育登录手机This application note demonstrates the resolution and robustness made possible with an Agilent TED in combination with an Agilent 1290 Infinity II Bio LC at elevated temperatures.
Application compendium for intact and subunit purity
Critical Quality Attributes Peptide Mapping compendium
Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
必威体育登录手机In this application note, a method is discussed for analyzing the deamidation of proteins using the Agilent AdvanceBio Peptide Mapping column and Agilent AdvanceBio Peptide Plus.
必威体育登录手机The use of an Agilent AdvanceBio Peptide Plus column with formic acid as a mobile phase modifier to analyze the synthetic peptide bivalirudin and its impurities.
必威体育赛事投注The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
This app note presents a complete high-throughput workflow solution for sequence mapping analysis.
This app note presents a high-throughput workflow that enables simultaneous, highly reproducible sample digestion and cleanup.
Comparative analysis using LC-QTOF/MS between innovator and biosimilar of Rituximab
必威体育登录手机This Application note demonstrates peptide mapping of a therapeutic mAb using Agilent 1260 Bio-inert Quaternary LC with fusion QbD method development software.
必威体育登录手机Reversed-phase LC primary structure characterization workflow using Agilent AdvanceBio RP-mAb columns and Agilent 1260 Infinity Bio-Inert LC system
必威体育登录手机An Agilent 2.7 µm HILIC column revealed a glycopeptide not seen by RP.HILIC can be orthogonal and complementary to RP for better retention of hydrophilic peptides.
This Application Note shows the workflow solution for the physicochemical and biological characterization of a biosimilar and innovator rituximab.
The charge heterogeneity provides a great challenge for the complete characterization of the monoclonal antibody (mAb).
This work describes a high flow LCMS method to demonstrate the high resolution mass analysis of mAbs with good chromatography and its utility in analysis of Biosimilar mAbs.
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