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This application note presents different approaches to native mass spectrometry.
During the drug discovery process, permeability assays such as Caco-2 (cell line) and PAMPA (parallel artificial membrane permeation assay) are utilized to mimic the absorption of potential drug candidates by the cells of the human intestine.
Do you want to open new avenues for pursuing small molecule and protein drug targets—without using surrogates, radioactivity, coupled assays, or indirect measurements?必威体育登录手机The Agilent RapidFire 400 high-throughput mass spectrometry system delivers...
必威体育登录手机This application note describes a method for automated MHC-I associated peptide enrichment using the Agilent AssayMAP Bravo platform with large-capacity (25 µL) cartridges for immunopeptidomics analysis.
必威体育登录手机This application note showcases the quantitative performance of multiple reaction monitoring (MRM)-based LC/MS analysis of peptides derived from protein biomarkers in human plasma using the Agilent 1290 Infinity II LC system coupled to the Agilent...
This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
This application note describes a robust LC/MS method for the analysis of native protein analysis.
A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MS
| Chinese (Simplified) (China) | Complete (PDF) |
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| Korean (Korea) | Complete (PDF) |
必威体育登录手机Describes a workflow for monitoring multiple mAb characteristics involving the Agilent 1290 Infinity II 2D-LC System.
必威体育登录手机This application note presents the use of the Agilent 6560 ion mobility LC/Q-TOF to analyze the formation of multimers of bovine serum albumin (BSA) in various mobile phases.
必威体育赛事投注The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
| Korean (Korea) | Complete (PDF) |
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| Chinese (Simplified) (China) | Complete (PDF) |
Critical Quality Attribute Monitoring of mAbs at the Intact and Subunit Levels
An automated workflow for the analysis of protein phosphorylation from sample preparation with phosphopeptide enrichment to analysis by IMS.
必威体育赛事投注The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
| Korean (Korea) | Complete (PDF) |
|---|---|
| Chinese (Simplified) (China) | Complete (PDF) |
This application note describes a method for quantitative analysis of intact monoclonal antibodies (mAbs) in a serum matrix.
Host cell protein quantification workflow of a mAb product using the 6495C LC/TQ with automated sample prep using AssayMAP Bravo.
| Korean (Korea) | Complete (PDF) |
|---|---|
| Japanese (Japan) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
必威体育登录手机Presents a method for protein analysis using an Agilent LC/MSD XT and 1260 Infinity II LC.
Identification of NISTmAb Charge Variants by Fully Automated Capillary Isoelectric Focusing and Mass Spectrometry