GenetiSure Pre-Screen Microarrays
The GenetiSure Pre-Screen microarray screens for DNA copy number variations and chromosomal aneuploidies in human cell samples collected from embryo biopsies and single cell samples.必威体育登录手机The system takes advantage of Agilent's dual-color CGH technology and uses a specific protocol that allows sample vs sample hybridization and analysis against both male and female reference samples for optimal results.
The microarrays have uniform, genome-wide probe coverage, with increased density on chromosomes 13, 18, 20, 21, 22 and X.These are the chromosomes associated with aneuploidy events, allowing sample-to-results in less than 24 hours.The complete kit solution includes the new amp and labeling bundle and all components needed to amplify and label up to 48 single-cell samples to maximize workflow efficiency with any throughput.A single cell aneuploidy detection workflow is also included in CytoGenomics software.
The microarrays have uniform, genome-wide probe coverage, with increased density on chromosomes 13, 18, 20, 21, 22 and X.These are the chromosomes associated with aneuploidy events, allowing sample-to-results in less than 24 hours.The complete kit solution includes the new amp and labeling bundle and all components needed to amplify and label up to 48 single-cell samples to maximize workflow efficiency with any throughput.A single cell aneuploidy detection workflow is also included in CytoGenomics software.
For Research Use Only.Not for use in diagnostic procedures.
Product Details
Features
- Increased density on chromosomes 13, 18, 20, 21, 22 and X enables sample-to-results in less than 24 hours
- High resolution screening to detect genomic aberrations down to 5Mb using the Single Cell Recommended Analysis Method, and as low as 1Mb using the Single Cell Small Aberration Method.
- Rapid identification of aneuploidies and copy number from samples with few cells like Blastomere (Day 3) or Trophectoderm (Day 5)
- A powerful single cell aneuploidy detection analysis workflow is included in CytoGenomics software.
- Efficient protocol enables processing up to 48 samples in less than 8h
- Amplification & labeling bundle with reagents included to process catalog or custom array formats
- Cost-effective screening from 6 or 14 samples/ experiment run (4x180K or 8x60K slide respectively)
- Probes are annotated against NCBI Build 38 (UCSC GRCh38, Dec.2013)
Featured References
- Publications
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- Pinto D et al.Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants.Nat Biotechnol.2011 May 8;29(6):512-20.doi: 10.1038/nbt.1852 [Application: General]Learn More
- Alesi V et al.Easychip 8x15k: A New Tool for Detecting Chromosome Anomalies in Low Risk Pregnancies, Supporting and Integrating Standard Karyotype J Genet Syndr Gene Ther 7: 277.doi:10.4172/2157-7412.1000277 [Application: Prenatal]Learn More
- Chau MHK et al.Characteristics and mode of inheritance of pathogenic copy number variants in prenatal diagnosis.Am J Obstet Gynecol.2019 Nov;221(5):493.e1-493.e11.doi: 10.1016/j.ajog.2019.06.007.Epub 2019 Jun 14.[Application: Prenatal]Learn More
